17th Annual ECSS-Congress, Bruges 2012

Abstract details

Abstract-ID: 991
Session: [PO-CPP-20] Physiology
Lecture room: Gallery
Date & time: 09.07.2016 / -
Title of the paper: Effect of 12 weeks exercise program on circulating levels of Wnt inhibitors in breast cancer survivors
Authors: Yeh, B., Kim, T., Chang, J., Kim, H., Kong, I.
Institution: Yonsei University Wonju College of Medicine
Department: Dept. of Medical Education
Country: Korea, South
Abstract text Introduction Dickkpof-1 (DKK1) and secreted frizzled-related protein-1 (SFRP1) are inhibitors of Wnt/β-catenin signaling. Accumulating evidence suggests that higher serum level of DKK1 is positively correlated with pathologic conditions such as cancer and atherosclerosis. Furthermore, DKK1 disrupts osteoblast differentiation and precipitates osteoporosis. Several recent studies showed that exercise reduces DKK1 level in healthy volunteers or experimental animals. We investigated the changes of serum levels of DKK1 and SFRP1, as Wnt/β-catenin inhibitors, by long-term exercise in breast cancer patients. Methods Twenty four breast cancer patients (50.411.8 years of age) after chemo- or radiotherapy were participated. Intervention groups were randomized to 12 wks of breast cancer exercise program (n = 11) or control group (n = 13). Blood samples were collected to examine the serum level of DKK1 and SFRP1. Results The serum levels of DKK1 (p < .01), SFRP1 (p < .01) and leptin (p < .05) were significantly reduced during 12 wks exercise program. However, those in control group were not changed during 12 wks. Also adiponectin/leptin ratio was significantly reduced during exercise program compared to control group (p < .05). The serum level of insulin was significantly decreased during 12wks exercise intervention (p < .05), but serum level of Hs-crp was not significant changed. Exercised group showed remarkable increases in health related fitness such as hand-grip strength, muscle endurance, flexibility (p < .05). Also, body fat percentage (p<.01), waist circumference and visceral fat area were significantly decreased in exercised group compared to control group (p < .05). Conclusion Our results suggest that long-term exercise decreases serum levels of DKK1 and SFRP1, which may contribute to the beneficial effects of exercise on physical fitness and metabolism in cancer patients. DKK1 and SFRP1 could be a therapeutic target for prevention of disease complications and improvement of metabolism. Contact Byung Il Yeh, MD, PhD: mia1@yonsei.ac.kr
Topic: Physiology
Keyword I: Breast cancer
Keyword II: Exercise
Keyword III: Wnt