17th Annual ECSS-Congress, Bruges 2012

Abstract details

Abstract-ID: 412
Session: [IS-PM10] New discoveries in cellular cross-talk between skeletal muscle, its microvascular endothelium and vital organs underpin the importance of an active lifestyle
Lecture room: 1.85 & 1.86
Date & time: 08.07.2016 / -
Title of the paper: Role of VEGF-A in exercise induced capillary growth and nutrient delivery to skeletal muscle
Authors: Hellsten, Y., Hoier, B.
Institution: University of Copenhagen
Department: Department of Exercise and Sport Sciences
Country: Denmark
Abstract text Capillarization in skeletal muscle correlates well with the level of oxidative capacity of the muscle and is readily altered in relation to the level of physical activity and inactivity. At a functional level, the size of the capillary net in skeletal muscle is important for optimal exchange of oxygen and nutrients and for insulin sensitivity. The process of capillary growth, or angiogenesis, is complex and involves orchestration of a number of proangiogenic and antiangiogenic factors of which vascular endothelial growth factor–A (VEGF-A) is known to be a central proangiogenic factor. VEGF-A is stored in relatively large amounts in skeletal muscle cells in vesicle-like structures. Upon muscle contraction or passive movement the VEGF-A containing vesicles are translocated to the muscle membrane for release to the extracellular space. Accordingly, in healthy young individuals, muscle interstitial levels of VEGF-A increase markedly during exercise and passive movement. This mechanism, which is thought to be an important step in the regulation of capillary growth in skeletal muscle, is impaired in aging and life style related disease and may be one of the underlying causes of microvascular rarefaction. VEGF-A is also present in capillary endothelial cells and pericytes and recent evidence suggests that pericytes also may contribute to angiogenesis in skeletal muscle. It is clear that capillary growth and oxygen and nutrient delivery depend on an interaction of endothelial cells with skeletal muscle cells and pericytes and future research should aim at addressing the precise mechanisms underlying this cellular cross-talk.
Topic: Physiology
Keyword I: Capillary
Keyword II: Exercise
Keyword III: Skeletal muscle