17th Annual ECSS-Congress, Bruges 2012

Abstract details

Abstract-ID: 395
Session: [MO-PM35] Hormones
Lecture room: E
Date & time: 07.07.2016 / -
Title of the paper: Prolonged Electrical Muscle Stimulation Increases Plasma Brain-Derived Neurotrophic Factor in Type 2 Diabetes
Authors: Miyamoto, T., Iwakura, T., Morino, T., Iwamoto, M., Takenaka, M., Akamatsu, Y., Matsuoka, N., Moritani, T.
Institution: Hyogo University of Health Sciences
Department: School of Rehabilitaion
Country: Japan
Abstract text Introduction Electrical muscle stimulation (EMS) is expected to be a candidate for new exercise method in the patients who have a difficulty in performing voluntary exercise. We provided the first evidence indicating that a single bout of EMS could effectively attenuate postprandial hyperglycemia in type 2 diabetes (T. Miyamoto et al., 2012; T. Miyamoto, Fukuda, Watanabe, Hidaka, & Moritani, 2015) and prolonged EMS could increase muscle strength and.cardiorespiratory fitness in healthy subjects (Toshiaki Miyamoto, Kamada, Tamaki, & Moritani). It has been considered that type 2 diabetes is closely related to the onset of nervous diseases such as cognitive impairment and diabetic neuropathy. Recently, brain-derived neurotrophic factor (BDNF) and insulin like growth factor-1 have been considered of exercise-induced neuroplasticity-related proteins. The purpose of this study was to evaluate the effect of prolonged EMS training on plasma BDNF and IGF-1 concentrations as well as metabolic parameters in type 2 diabetes. Methods Fourteen men outpatients with type 2 diabetes participated in this study (Age: 63.4±11.0 years, BMI: 27.0±4.6, HbA1c: 7.7±0.6%). In a randomized crossover trial, patients were evaluated at baseline and after two 8-week periods (control and EMS training) for body composition, estimated energy intake, physical activity and blood measurements (glucose and fat metabolic parameters, IGF-1, BDNF). Each patients performed 40-min EMS training, 4 days per week, during 8-week EMS training period while maintaining daily lifestyle during 8-week control period. Student’s t-test or Wilcoxon test were used to compare the absolute changes of measurements between periods. Results There were not significant differences in estimated energy intake and physical activity between periods. It was found that EMS training significantly attenuated body fat and fasting glucose level (P<0.05). Also, EMS training induced significant higher plasma BDNF (P<0.05). However, significant differences were not found in the other evaluations. Discussion Our present study showed that prolonged EMS training induced significant lower body fat and fasting glucose level and higher plasma BDNF. This study suggested that EMS can be an alternative exercise method to improve cognitive function as well as metabolism for the patients who cannot perform voluntary exercise. References Miyamoto, T., Fukuda, K., Kimura, T., Matsubara, Y., Tsuda, K., & Moritani, T. (2012). Diabetes Res Clin Pract, 96(3), 306-312. Miyamoto, T., Fukuda, K., Watanabe, K., Hidaka, M., & Moritani, T. (2015). J Electromyogr Kinesiol, 25(1), 136-142. Miyamoto, T., Kamada, H., Tamaki, A., & Moritani, T. (In press). European Journal of Sport Science. t-miyamoto@huhs.ac.jp
Topic: Rehabilitation and Physiotherapy
Keyword I: Electrical Muscle Stimulation
Keyword II: brain-derived neurotrophic factor
Keyword III: type 2 diabetes